Sodium Hydroxide → HCID 22916386, compound

HRID 265389Notes

Reaction equation

C([O:3][C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:16]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:15]=[C:14]1[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])=[O:5])C.[OH-].[Na+]>>[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:16]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:15]=[C:14]1[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])([OH:5])=[O:3]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 22916345HCID 22916345, compound

Product 1

HCID 22916386HCID 22916386, compound

Procedure

1-(7-Ethoxycarbonylheptyl)-2-heptyl-4,5-diphenylimidazole (1 g) was reacted with sodium hydroxide in a method similar to Example 10 to give, after column chromatography on silica gel (dichloromethane/methanol) and recrystallisation from hexane, 1-(7-carboxyheptyl)-2-heptyl-4,5-diphenylimidazole (0.26 g, 28%) as a white solid, m.p. 75°-6°. Found: C, 78.04; H, 8.85; N, 6.10%; C30H40N2O2 requires: C, 78.22; H, 8.75; N, 6.08%;

Workup

customto give
customafter column chromatography on silica gel (dichloromethane/methanol) and recrystallisation from hexane, 1-(7-carboxyheptyl)-2-heptyl-4,5-diphenylimidazole (0.26 g, 28%) as a white solid, m.p. 75°-6°

Sources & evidence

ORD record: ord-7c9b1f78367847e9996e215e629b78e6
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05648373

Reaction notes

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