Methyl iodide → Ethyl 3-methylamino-4-cyclohexylphenylglyoxylate

HRID 26549Notes

Reaction equation

HRID 26549 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[CH3:21]I>N1C=CC=CC=1>[CH3:21][NH:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20515218Ethyl 3-amino-4-cyclohexylphenylglyoxylate

Product 1

HCID 20515175Ethyl 3-methylamino-4-cyclohexylphenylglyoxylate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 0.01 moles of ethyl 3-amino-4-cyclohexylphenylglyoxylate in 100 ml. of pyridine is added 0.1 moles of methyl iodide. The reaction mixture is stirred overnight at room temperature, filtered and concentrated. The residue is distilled to obtain ethyl 3-methylamino-4-cyclohexylphenylglyoxylate.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated
  3. distillationThe residue is distilled

Sources & evidence

ORD record
ord-a2e369448a4f40eea2bd19b445797bbb
Source dataset
uspto-grants-1979_04
Patent number
US04150148

Reaction notes

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