Methanol → 3,4,5,6-Tetrafluorophthalic acid-monomethyl ester

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Reaction Steps

Into a 100 ml glass reactor equipped with a reflux condenser and a stirrer, 20 g (0.091 mol) of the tetrafluorophthalic anhydride prepared in Example 3 and 40 ml of methanol were charged, and the mixture was stirred for 2 hours under reflux. After completion of the reaction, methanol was distilled off to obtain 22.5 g of 3,4,5,6-tetrafluorophthalic acid-monomethyl ester. The yield was 98.0%.

Provenance & Evidence