反应详情

1.32 g (10 mmol) of trans-3-amino-4-methylthiopyrrolidine are initially introduced into 5 ml of methanol, and 1.23 ml (11 mmol) of 97% strength pivalaldehyde are added dropwise, after which the temperature rises from 25° to 36° C. The mixture is subsequently stirred for a further 30 minutes, without cooling, the batch is then concentrated and the residue is distilled. Yield: 1.50 g (75% of theory), boiling point: 63° C./0.07 mbar.

1. additionare added dropwise
2. customrises from 25° to 36° C
3. temperaturewithout cooling
4. concentrationthe batch is then concentrated
5. distillationthe residue is distilled