Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Azide → N-Boc-4-(2-azidoethyl)piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | Tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylate | HCID 9974426 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-Boc-4-(2-azidoethyl)piperidine | HCID 23282934 | — |
반응 단계
To 1-4 (27.9 g, 0.082 moles) dissolved in DMSO (400 ml) was added sodium azide (5.61 g, 0.086 moles) at room temperature and the resulting solution was heated at 65° for 2 hrs. The cooled reaction mixture was diluted with 250 ml EtOAc, extracted with 2×100 ml portions of water, 2×50 ml portions of brine and then dried (MgSO4). Solvent removal provided 1-5 as a pale yellow oil, Rf 0.5 (silica gel, 20% acetone/hexane). ##STR13##
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05648368 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-ec27af140ab349c7be387d9655a832c7 |
| 출처 메모 | uspto-grants-1997_07 |