1,3-Benzenedicarboxylic acid, 4-methyl-, 1,3-dimethyl ester → 4-Methylbenzene-1,3-dicarboxylic acid

Participants

Reaction Steps

A solution of 2-20 (1.5 g, 7.2 mmoles) in THF/MeOH/H2O (1:1:1) (36 ml) at room temperature was treated with LiOH.H2O (1.5 g, 36 mmoles). After stirring for 3 hours, the solvent was removed and the residue acidified with 1N HCl. This was extracted with EtOAc, and the extract was dried (MgSO4) and concentrated to give 2-21.

Provenance & Evidence