HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 2-(S)-[N-carbobenzyloxy]amino-3-aminopropionate, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Z-Dap-OH | HCID 2756313 | — |
| Product | Methyl 2-(S)-[N-carbobenzyloxy]amino-3-aminopropionate, hydrochloride | HCID 13756825 | — |
Reaction Steps
3-Amino-2(S)-benzyloxycarbonylaminopropionic acid (Fluka) (5.0 g, 21.0 mmoles) was suspended in MeOH and at -10° SOCl2 (23.0 mmoles) was added. The reaction mixture was allowed to gradually warm to room temperature over 16 hours. The solvent was then removed and the resulting solid was triturated with Et2O to give 10-10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05648368 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-5a924f8037854292836f3242c3d9f59d |
| Source note | uspto-grants-1997_07 |