HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 19034123, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-tert-Butyl-beta-alanine--hydrogen chloride (1/1) | HCID 17567357 | — |
| Reactant | HCID 19034073 | HCID 19034073 | — |
| Product | HCID 19034123 | HCID 19034123 | — |
Reaction Steps
To a stirred solution of 11-7 (275 mg, 0.79 mmoles), HOBT (130 mg, 0.95 mmoles), N(i-Pr)2Et (0.55 mL, 3.2 mmoles), tert-butyl-β-alanine hydrochloride (160 mg, 0.95 mmoles), and DMF (4 mL), at -15° C. was added EDC (183 mg, 0.95 mmoles) followed by removal of the cooling bath. After 20 hours the reaction mixture was diluted with EtOAc and then washed with H2O, saturated NaHCO3, 10% KHSO4, and brine, dried (MgSO4), and concentrated. Flash chromatography (silica, 50% EtOAc/hexanes) gave 11-8 as a colorless oil. Rf 0.21 (silica, 50% EtOAc/hexanes).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05648368 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-6b417981ff1b436c9e32fb68a6d9479c |
| Source note | uspto-grants-1997_07 |