HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Ethyl 3-[4-(N-BOC-hydroxypiperidin-4-yl)phenyl]butyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ethyl 3-[4-(N-BOC-4-hydroxypiperidin-4-yl)phenyl]crotonate | HCID 67721045 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | Ethyl 3-[4-(N-BOC-hydroxypiperidin-4-yl)phenyl]butyrate | HCID 19034119 | — |
Reaction Steps
A mixture of 12-1 (400 mg, 1.0 mmoles), 10% Pd/C (160 mg), and CH3OH (5 mL) was stirred at ambient temperature under a hydrogen atmosphere for 3.0 hours. The reaction mixture was filtered through a celite pad and the filtrate concentrated to give 12-2 as a yellow oil. Rf 0.33 (silica, 30% EtOAc/hexanes).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05648368 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-452d160c4ea84adc9e7602413fe534c7 |
| Source note | uspto-grants-1997_07 |