Lithium Hydroxide → HCID 19034100, compound

Participants

Reaction Steps

A solution of 14-2 (650 mg, 1.2 mmol), 1N LiOH (3 mL), and THF (5 mL) was stirred at ambient temperature for 20 h. The reaction mixture was then washed with EtOAc followed by acidification with 5% KHSO4, then extraction with EtOAc. The EtOAc extract was washed with brine, dried (MgSO4) and concentrated to give 14-3 (260 mg) as a white solid. Rf 0.64 (silica, 10:2:2 (CH2Cl2 /CH3OH/AcOH).

Provenance & Evidence