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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 265877Generated: October 27, 2026

Ethanol ammonium hydroxide water → 3-Chloro-4-[2-(piperidin-4-yl)ethyloxy]phenylcarbonyl-2(S)-phenylsulfonylamino-beta-alanine

https://huagongshe.com/reaction/265877

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanol ammonium hydroxide waterHCID 86596525—
Reactant3-Chloro-4-[2-(N-BOC-piperidin-4-yl)ethyloxy]phenylcarbonyl-2(S)-phenylsulfonylamino-beta-alanine Methyl EsterHCID 86751085—
Product3-Chloro-4-[2-(piperidin-4-yl)ethyloxy]phenylcarbonyl-2(S)-phenylsulfonylamino-beta-alanineHCID 8675108436.2%

Reaction Steps

Utilizing the procedure for convening 9-5 to 9-6, 15-5 (275 mg, 0.46 mmol) gave 15-6 (85 mg) after flash chromatography (silica, 10:1:1 ethanol/H2O/NH4OH). Rf 0.39 (silica, 10:1:1 ethanol/H2O/NH4OH).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05648368
Source datasetuspto-grants-1997_07
ORD IDord-f69f25ef34834dca9c798ed218b5ad02
Source noteuspto-grants-1997_07