HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 10457992, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | (2S)-3-amino-2-(benzenesulfonamido)propanoic Acid | HCID 10752796 | — |
| Reactant | 4-[3-(Pyridin-4-yl)propyloxy]benzoic acid | HCID 19034145 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10457992 | HCID 10457992 | 106.1% |
Reaction Steps
A solution of 19-5 (200 mg, 0.78 mmol), NEt3 (0.22 mL, 1.5 mmol), and DMF (4 mL) at ambient temperature was treated with BOP (345 mg, 0.78 mmol). After 3.0 h, NEt3 (0.22 mL, 1.5 mmol) and 19-2 (190 mg, 0.78 mmol) were added. After 20 h, the reaction mixture was concentrated and subjected to flash chromatography (silica, 10/1/1 CH2Cl2 /CH3OH/AcOH) to give impure 19-6 (400 mg). Prep HPLC purification (Delta Pak C-18Å column, 0 to 100% CH3CN/H2O containing 0.1% trifluoroacetic acid) gave pure 19-6 as a whim solid after lyophilization. Rf 0.74 (silica, 10/1/1 CH2Cl2 /CH3OH/AcOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05648368 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-9a3be4b102b74f0a80c4affd98609cfc |
| Source note | uspto-grants-1997_07 |