Sodium Hydroxide → HCID 19034181, compound

Participants

Reaction Steps

A solution of 21-5 (1.6 g, 4.1 mmol), ethanol (41 mL), and 1N NaOH (21 mL) was stirred at ambient temperature for 20 hours. The reaction was then concentrated and the residue dissolved in H2O and then washed with ether. The aqueous phase was acidified with 5% KHSO4 and then extracted with EtOAc. The EtOAc portion was washed with 5% KHSO4 and brine, dried (MgSO4), and concentrated to furnish 21-6 as a white solid. TLC Rf =0.68 (silica, acetone);

Provenance & Evidence