HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Methylmorpholine → 4-(4-Chlorobutyloxy)benzoyl-2(S)-phenylsulfonylamino-beta-alanine tert-butylester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Methylmorpholine | HCID 7972 | — |
| Edukt | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Edukt | 4-(4-Chlorobutyloxy)benzoic acid | HCID 19034175 | — |
| Edukt | (S)-3-amino-2-benzenesulfonylamino-propionic acid tert-butyl ester hydrochloride | HCID 22853534 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | 4-(4-Chlorobutyloxy)benzoyl-2(S)-phenylsulfonylamino-beta-alanine tert-butylester | HCID 86751090 | — |
Reaktionsschritte
A stirring solution of 24-3 (250 mg, 1.1 mmol), 19-2a (368 mg, 1.1 mmol), NMM (442 mg, 4.4 mmol), and CH3CN (5 mL) at ambient temperature was treated with BOP (483 mg, 1.1 mmol). After 20 h the reaction mixture was diluted with EtOAc and then washed with H2O, sat. NaHCO3, 10% KHSO4 and brine, dried (MgSO4) and concentrated. Flash chromatography (silica, 40% EtOAc/hexanes) gave 24-4 as a white solid. TLC Rf =0.46 (silica, 50% EtOAc/hexanes);
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05648368 |
| Quelldatensatz | uspto-grants-1997_07 |
| ORD ID | ord-4ecbe887068e4629b2d2c3c4e709d415 |
| Quellennotiz | uspto-grants-1997_07 |