HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Methyl 4-(2-Pyrrolidinylethyloxy)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(2-Chloroethyl)pyrrolidine hydrochloride | HCID 81668 | — |
| Reactant | 4-[2-(Diethylamino)ethoxy]benzoic acid | HCID 13439087 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 4-(2-Pyrrolidinylethyloxy)benzoate | HCID 18617411 | — |
Reaction Steps
Compound 23-2 (2 g, 11.8 mmol) and chloroethylpyrrolidine·HCl (Aldrich) (1.8 g, 11.8 mmol) were treated with NaH (0.94 g, 23.6 mmol) in DMF (30 mL) as described for 27-1 to give 27-6 as a clear oil. Rf (10% MeOH/CHCl3 saturated with NH3) 0.4
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05648368 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-ee375870410c44d6a74c6035867c4f20 |
| Source note | uspto-grants-1997_07 |