反应详情

温度

55 °C

A stirred solution of 33-4 (0.96 g, 3.9 mmol) in ether (20 mL) at ambient temperature was treated with LiBH4 (0.34 g, 15.8 mmol) then heated to 55° C. After 45 min the cooled reaction was quenched with 5% KHSO4 (10 mL) and then diluted with EtOAc. The organic phase was washed with 5% KHSO4 and brine, dried (MgSO4), and concentrated to give 33-5 (0.79 g) as a colorless oil. Rf 0.46 (silica, EtOAc).

1. customAfter 45 min the cooled reaction
2. customwas quenched with 5% KHSO4 (10 mL)
3. additiondiluted with EtOAc
4. washThe organic phase was washed with 5% KHSO4 and brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated