HRID265926

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3017129

4-Phenylpiperidine-4-carboxamide monohydrochloride

C12H17ClN2O

结构：CCOc1cc(C(=O)N2CCC(CCCS(=O)(=O)[O-])(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC

HCID86750914

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC

HCID53655323

未命名化合物

PROCEDURE

实验过程

Prepare by the method of example 3.3 using 2-[3-(3,4-dimethoxy-phenyl)-1-(3,4,5-triethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (8 mmol) and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (12 mmol). Chromatograph on silica gel to give the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e2c004a8d6824dffb28318954dc090ab
来源数据集: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05648366
来源说明: uspto-grants-1997_07

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2([CH2:33][CH2:34]CS([O-])(=O)=O)[CH2:15][CH2:14][N:13]([C:16](=[O:32])[C:17]3[CH:22]=[C:21]([O:23][CH2:24][CH3:25])[C:20]([O:26][CH2:27][CH3:28])=[C:19]([O:29][CH2:30][CH3:31])[CH:18]=3)[CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl.[C:41]1([C:47]2([C:53]([NH2:55])=[O:54])[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]2)[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2([CH2:33][CH2:34][N:50]3[CH2:49][CH2:48][C:47]([C:41]4[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=4)([C:53]([NH2:55])=[O:54])[CH2:52][CH2:51]3)[CH2:15][CH2:14][N:13]([C:16](=[O:32])[C:17]3[CH:18]=[C:19]([O:29][CH2:30][CH3:31])[C:20]([O:26][CH2:27][CH3:28])=[C:21]([O:23][CH2:24][CH3:25])[CH:22]=3)[CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]