反应详情

Combine 3-isopropoxy-phenyl-acetic acid isopropyl ester 10.2 g, 43.2 mmol) and sodium hydroxide (2.08 g, 51.8 mmol) in 1/1 ethanol/water (80 mL). Heat to reflux. After 18 hours, remove the ethanol by evaporation in vacuo and acidify to pH=1 using an aqueous solution with 1M hydrochloric acid solution. Extract the aqueous solution 3 times with ethyl acetate. Extract the combined organic layers with water and saturated sodium chloride solution. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to obtain 3-isopropoxy-phenyl-acetic acid.

1. temperatureHeat to reflux
2. customremove the ethanol
3. customby evaporation in vacuo
4. extractionExtract the aqueous solution 3 times with ethyl acetate
5. extractionExtract the combined organic layers with water and saturated sodium chloride solution
6. dry with materialDry the organic layer over MgSO4
7. filtrationfilter
8. customevaporate in vacuo