HCID 67697109, compound → HCID 54021069, compound

HRID 265953Notes

Reaction equation

HRID 265953 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:28][CH2:29]CS([O-])(=O)=O)[CH2:13][CH2:12][N:11]([C:14](=[O:27])[C:15]3[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].FC(F)(F)C(O)=O.[CH2:42]([N:49]1[C:53](=[O:54])[C:52]2([CH2:59][CH2:58][NH:57][CH2:56][CH2:55]2)[N:51]([C:60]2[CH:65]=[CH:64][C:63]([F:66])=[CH:62][CH:61]=2)[CH2:50]1)[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1>>[CH2:42]([N:49]1[C:53](=[O:54])[C:52]2([CH2:59][CH2:58][N:57]([CH2:29][CH2:28][C:9]3([C:4]4[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=4)[CH2:13][CH2:12][N:11]([C:14](=[O:27])[C:15]4[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=4)[CH2:10]3)[CH2:56][CH2:55]2)[N:51]([C:60]2[CH:65]=[CH:64][C:63]([F:66])=[CH:62][CH:61]=2)[CH2:50]1)[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1

Participants

3

Reactant 2

HCID 67697109HCID 67697109, compoundHCID 867509062-[1-(3,4,5-Trimethoxy-benzoyl)-3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate

Product 1

HCID 54021069HCID 54021069, compound

Procedure

Prepare by the method of example 3.3 using 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (5 mmol) and 3-benzyl-1-(4-fluoro-phenyl)-1,3,8-triaza-spiro[4.5]decan-4-one trifluoroacetate (7.5 mmol, 1.5 eq.). Chromatograph on silica gel to give the title compound.

Sources & evidence

ORD record
ord-784192767ddc43289f3e14702136b167
Source dataset
uspto-grants-1997_07
Patent number
US05648366

Reaction notes

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