Carbon tetrabromide → 2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl-bromide

Participants

Role	Name	HCID	Charge
Reactant	Carbon tetrabromide	HCID 11205	—
Reactant	Triphenylphosphine	HCID 11776	—
Reactant	4-(3,4-Dichloro-phenyl)-4-2-hydroxy-ethyl-1-(3,4,5-trimethoxy-benzyl)-pyrrolidine	HCID 54409184	—
Product	2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl-bromide	HCID 53709262	—

Reaction Steps

Prepare according to the method of example 57.7 using 4-(3,4-dichloro-phenyl)-4-2-hydroxy-ethyl-1-(3,4,5-trim ethoxy-benzyl)-pyrrolidine (5 mmol), carbon tetrabromide (6.3 mmol), and triphenylphosphine (7.5 mmol). Purify to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05648366
Source dataset	uspto-grants-1997_07
ORD ID	ord-44a5d40ac0914180af59a0aa8091d624
Source note	uspto-grants-1997_07