HRID265970

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3017129

4-Phenylpiperidine-4-carboxamide monohydrochloride

C12H17ClN2O

HCID21226206

未命名化合物

结构：CCOc1cc(C(=O)N2CCC(CCCS(=O)(=O)[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OCC)c1OCC

HCID86750929

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OCC)c1OCC

HCID54418731

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

Prepare by the method of example 27.3.1 using 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-triethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate ((1 mmol) and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (0.29 g, 1.2 mmol). Chromatograph on silica gel eluting sequentially with 50% ethyl acetate/hexane and then 6% methanol/dichloromethane to give the title compound: Rf =0.36 (silica gel, 10% methanol in dichloromethane). Exact mass (FAB+): calculated for C37H46Cl2N3O5 calculated 682.2815. Found 682.2799.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-32c3816f57264603b2b96a12ee7551f2
来源数据集: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05648366
来源说明: uspto-grants-1997_07

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:31][CH2:32]CS([O-])(=O)=O)[CH2:13][CH2:12][N:11]([C:14](=[O:30])[C:15]3[CH:20]=[C:19]([O:21][CH2:22][CH3:23])[C:18]([O:24][CH2:25][CH3:26])=[C:17]([O:27][CH2:28][CH3:29])[CH:16]=3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[C:39]1([C:45]2([C:51]([NH2:53])=[O:52])[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1.C(OCC)(=O)C.CCCCCC>CO.ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:31][CH2:32][N:48]3[CH2:47][CH2:46][C:45]([C:39]4[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=4)([C:51]([NH2:53])=[O:52])[CH2:50][CH2:49]3)[CH2:13][CH2:12][N:11]([C:14](=[O:30])[C:15]3[CH:20]=[C:19]([O:21][CH2:22][CH3:23])[C:18]([O:24][CH2:25][CH3:26])=[C:17]([O:27][CH2:28][CH3:29])[CH:16]=3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]