Triethylamine → HCID 86751111, compound

Participants

Reaction Steps

A solution of N6 -(phenylmethoxy)carbonyl-N2 -[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-L-lysine 27.5 g) in MeOH (600 ml), kept at room temperature and under nitrogen atmosphere, was added to p-toluenesulfonic acid monohydrate (1.56 g; 8.2 mmol). After 20 h the reaction mixture was added to Et3N (0.832 g; 8.2 mmol). The mixture was evaporated under reduced pressure and the resulting crude was purified by flash chromatography to obtain the desired product (24.1 g; 35.2 mmol).

Provenance & Evidence