HCID 67714532, compound → HCID 56632723, compound

Participants

Reaction Steps

The acetoxy compound (Compound 1.2) (4 mg, 14 μmole) was dissolved in 4 mL of a solution of 5% K2CO3 and methanol (1 to 1 ratio). After 6 hours of stirring at room temperature, the reaction mixture was evaporated to half of the original volume for CHCl3 -H2O extraction. Then, the organic layer was dried over MgSO4 and filtered, and the solvent was removed under reduced pressure. Purification by flash silica column chromatography yielded the hydroxy compound (Compound 1.3) in quantitative yield. 1H NMR (300 MHz, CDCl3) δ 8.04 (2H, m), 7.55 (2H, m), 7.31 (1H, s), 4.45 (1H, t), 3.42(2H, m), 2.95 (2H, t), 2.69 (6H, s), 1.64 (2H, m).

Provenance & Evidence