反应详情

Aqueous 2.5 N sodium hydroxide solution 433 ml was added to methanol solution 1125 ml of 2-adamantyl acetic acid methyl ester 150 g (0.72 mol) and stirred at room temperature for 6 hours. Reaction mixture was concentrated in vacuo. Aqueous sodium bicarbonate solution was added to the residue and the mixture was washed with ether. Aqueous layer was adjusted to pH 1 by adding 12 N hydrochloric acid, extracted with ethyl acetate and dried with anhydrous sodium sulfate.

1. customReaction mixture
2. concentrationwas concentrated in vacuo
3. additionAqueous sodium bicarbonate solution was added to the residue
4. washthe mixture was washed with ether
5. additionby adding 12 N hydrochloric acid
6. extractionextracted with ethyl acetate
7. dry with materialdried with anhydrous sodium sulfate