Ethyl 4-chloro-2,6-dimethylnicotinate → Ethyl 2,6-dimethyl-4-[2-(2,4-dimethylphenoxy)ethylamino]nicotinate

HRID 266106Notes

Reaction equation

HRID 266106 reaction equation
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([CH3:13])[N:5]=[C:4]([CH3:14])[CH:3]=1.[CH3:15][C:16]1[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:17]=1[O:18][CH2:19][CH2:20][NH2:21]>>[CH3:13][C:6]1[N:5]=[C:4]([CH3:14])[CH:3]=[C:2]([NH:21][CH2:20][CH2:19][O:18][C:17]2[CH:22]=[CH:23][C:24]([CH3:26])=[CH:25][C:16]=2[CH3:15])[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

3

Reactant 2

HCID 239536Ethyl 4-chloro-2,6-dimethylnicotinateHCID 27942062-(2,4-Dimethylphenoxy)ethanamine

Product 1

HCID 19032588Ethyl 2,6-dimethyl-4-[2-(2,4-dimethylphenoxy)ethylamino]nicotinate

Procedure

was synthesized analogously to Example 8 using ethyl 4-chloro-2,6-dimethylnicotinate and 2-(2,4-dimethylphenoxy)ethylamine.

Sources & evidence

ORD record
ord-15740ca564ce4775ab1904aa38b2e94f
Source dataset
uspto-grants-1997_07
Patent number
US05650417

Reaction notes

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