4-Amino-2,2,6,6-tetramethylpiperidine → Ethyl 2,6-dimethyl-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)nicotinate

HRID 266107Notes

Reaction equation

HRID 266107 reaction equation
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([CH3:13])[N:5]=[C:4]([CH3:14])[CH:3]=1.[CH3:15][C:16]1([CH3:25])[CH2:21][CH:20]([NH2:22])[CH2:19][C:18]([CH3:24])([CH3:23])[NH:17]1>>[CH3:13][C:6]1[N:5]=[C:4]([CH3:14])[CH:3]=[C:2]([NH:22][CH:20]2[CH2:21][C:16]([CH3:25])([CH3:15])[NH:17][C:18]([CH3:24])([CH3:23])[CH2:19]2)[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

3

Reactant 2

HCID 375244-Amino-2,2,6,6-tetramethylpiperidineHCID 239536Ethyl 4-chloro-2,6-dimethylnicotinate

Product 1

HCID 19032608Ethyl 2,6-dimethyl-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)nicotinate

Procedure

was synthesized analogously to Example 8 using ethyl 4-chloro-2,6-dimethylnicotinate and 2,2,6,6-tetramethyl-4-aminopiperidine. M.p.: 89° to 90° C.

Sources & evidence

ORD record
ord-c8276f70e22d4d1ea31945017757c408
Source dataset
uspto-grants-1997_07
Patent number
US05650417

Reaction notes

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