HCID 19032513, compound → HCID 19032545, compound

HRID 266110Notes

Reaction equation

HRID 266110 reaction equation
O1[C:5]2([CH2:10][CH2:9][CH:8]([NH:11][C:12]3[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][O:19][CH3:20])[C:13]=3[O:21][CH3:22])[CH2:7][CH2:6]2)[O:4]CC1>C(O)=O>[O:4]=[C:5]1[CH2:10][CH2:9][CH:8]([NH:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][O:19][CH3:20])[C:13]=2[O:21][CH3:22])[CH2:7][CH2:6]1

Participants

3

Reactant 1

HCID 19032513HCID 19032513, compound

Product 1

HCID 19032545HCID 19032545, compoundYield 89.9%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

4.4 g of 4-(1,4-dioxaspiro[4,5]dec-8-yl)amino-3-methoxy-2-methoxymethylpyridine (Example 59) is left to stand in 100 ml of 98% formic acid for 17 hours. The mixture is then concentrated, and the residue is extracted by shaking with 2N NaOH and CH2Cl2. After the organic phase has been concentrated, 3.4 g=89.9% of crystals are obtained.

Workup

  1. concentrationThe mixture is then concentrated
  2. extractionthe residue is extracted
  3. concentrationAfter the organic phase has been concentrated

Sources & evidence

ORD record
ord-e349de3f0a094da9bb41f29e62c14ead
Source dataset
uspto-grants-1997_07
Patent number
US05650417

Reaction notes

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