HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 6,7-Dimethoxy-4-(3,4-dimethoxyphenyl)-2-methylquinoline-3-carboxylic acid propyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Propyl acetoacetate | HCID 74507 | — |
| Reactant | 2-Amino-4,5,3',4'-tetramethoxybenzophenone | HCID 9926967 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6,7-Dimethoxy-4-(3,4-dimethoxyphenyl)-2-methylquinoline-3-carboxylic acid propyl ester | HCID 21851159 | 79% |
Reaction Steps
Conc. sulfuric acid was added to a mixture of 2-amino-4,5,3',4'-tetramethoxybenzophenone, propylacetoacetate and acetic acid. The mixture was treated according to the same manner as in Reference Example 1 to give propyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-methylquinoline-3-carboxylate (79%). This compound was recrystallized from ethyl acetateisopropyl ether. Colorless prisms, mp. 153°-155° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05650410 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-1433fbcf21f1494ba7871cc79d09194a |
| Source note | uspto-grants-1997_07 |