Morpholine → HCID 19032367, compound

Participants

Reaction Steps

A mixture of ethyl 2-chloromethyl-6,7-dimethoxy-4-(4-methoxyphenyl)quinoline-3-carboxylate (2.0 g), morpholine (2.5 g) and methanol (30 ml) was stirred at room temperature for 17 hours. The reaction mixture was concentrated under reduced pressure, and dichloromethane was added to the residue. The mixture was washed with water and dried over magnesium sulfate, and the solvent was evaporated. The resulting crystals were separated by filtration and recrystallized from ethanol to give ethyl 6,7-dimethoxy-4-(4-methoxyphenyl)-2-morpholinomethylquinoline-3-carboxylate (1.65 g, 74%). Colorless prisms, mp. 165°-166° C.

Provenance & Evidence