Morpholine → HCID 19032339, compound

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Reaction Steps

A mixture of ethyl 2-chloromethyl-6,7-dimethoxy-4-(2-methoxyphenyl)quinoline-3-carboxylate (1.0 g), morpholine (1.25 g) and ethanol (13 ml) was stirred at room temperature for 3 days. The precipitated crystals were separated by filtration and recrystallized from ethyl acetate-hexane to give ethyl 6,7-dimethoxy-4-(2-methoxyphenyl)-2-morpholinomethylquinoline-3-carboxylate (0.76 g, 68%). Colorless prisms, mp. 153°-154° C.

Provenance & Evidence