Aniline → HCID 19032346, compound

HRID 266159Notes

Reaction equation

HRID 266159 reaction equation
Cl[CH2:2][C:3]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=2)[C:10]2[C:5](=[CH:6][C:7]([O:25][CH3:26])=[C:8]([O:23][CH3:24])[CH:9]=2)[N:4]=1.[NH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[NH:27]([CH2:2][C:3]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=2)[C:10]2[C:5](=[CH:6][C:7]([O:25][CH3:26])=[C:8]([O:23][CH3:24])[CH:9]=2)[N:4]=1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 107856562-Chloromethyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazoline

Product 1

HCID 19032346HCID 19032346, compound

Procedure

According to the same manner as that described in Example 56, 2-chloromethyl-4- (3,4-dimethoxyphenyl ) -6,7-dimethoxyquinazoline was reacted with aniline to give 2-anilinomethyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazoline. This compound was recrystallized from ethanol. Colorless prisms, mp. 199°-200° C.

Sources & evidence

ORD record
ord-2ca050c7a86149a2aa73f0015d689828
Source dataset
uspto-grants-1997_07
Patent number
US05650410

Reaction notes

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