4-Chlorophenylboronic acid → 4-Chloro-3'-Cyclopentyloxy-4'-methoxy-biphenyl

HRID 266202Notes

Reaction equation

HRID 266202 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.[CH:11]1([O:16][C:17]2[CH:18]=[C:19](Br)[CH:20]=[CH:21][C:22]=2[O:23][CH3:24])[CH2:15][CH2:14][CH2:13][CH2:12]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:19]2[CH:20]=[CH:21][C:22]([O:23][CH3:24])=[C:17]([O:16][CH:11]3[CH2:12][CH2:13][CH2:14][CH2:15]3)[CH:18]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 99703924-Bromo-2-(cyclopentyloxy)-1-methoxybenzene

Product 1

HCID 187788514-Chloro-3'-Cyclopentyloxy-4'-methoxy-biphenylYield 92%

Procedure

Following the procedure of Example 1, 4-chloro-phenylboronic acid and 3-cyclopentyloxy-4-methoxybromobenzene yielded 92% of the title compound as white needles: mp 94°-95° C.

Sources & evidence

ORD record
ord-b144672895494b468c98a471308da00c
Source dataset
uspto-grants-1997_07
Patent number
US05650444

Reaction notes

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