HCID 22098889, compound → HCID 54016665, compound

HRID 266218Notes

Reaction equation

HRID 266218 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[CH:26][C:25]([C:28]([NH:30][CH2:31][CH2:32][C:33]([O:35][CH3:36])=[O:34])=[O:29])=[CH:24][CH:23]=3)[C:18]2=[O:37])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[H][H]>CO.[Pd]>[CH3:36][O:35][C:33]([CH2:32][CH2:31][NH:30][C:28]([C:25]1[CH:24]=[CH:23][C:22]([N:19]2[CH2:20][CH2:21][N:17]([CH:14]3[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]3)[C:18]2=[O:37])=[CH:27][CH:26]=1)=[O:29])=[O:34]

Participants

5

Reactant 2

HCID 22098889HCID 22098889, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54016665HCID 54016665, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Prepared by treating 1-(1-benzyloxycarbonyl-4-piperidinyl)-3-[4-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-phenyl]-imidazolidin-2-one with hydrogen at 3 bars in the presence of 5% palladium/charcoal in methanol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-87ff5263fc4242c5b07ef133a0fea7fe
Source dataset
uspto-grants-1997_07
Patent number
US05650424

Reaction notes

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