Ethanol → Ethyl [2-(3-Hydroxypropyl)phenyl]acetate

HRID 26625Notes

Reaction equation

HRID 26625 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][C:12]([OH:14])=[O:13].S(=O)(=O)(O)O.[CH2:20](O)[CH3:21]>>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][C:12]([O:14][CH2:20][CH3:21])=[O:13]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 20386052[2-(3-Hydroxypropyl)phenyl]acetic acid

Product 1

HCID 53980166Ethyl [2-(3-Hydroxypropyl)phenyl]acetate

Procedure

A solution of [2-(3-hydroxypropyl)phenyl]acetic acid (48.6 g., 0.25 mole) and sulfuric acid (3 ml.) in ethanol (400 ml.) is heated at reflux for 6 hours. Workup as described in Example 25, Step A(3) yields the title compound.

Workup

  1. temperatureat reflux for 6 hours

Sources & evidence

ORD record
ord-7976e6fe24854c5a85ac436be9e6fcbe
Source dataset
uspto-grants-1979_04
Patent number
US04150235

Reaction notes

Loading…