反应详情

To a solution of ethyl [2-(3-hydroxypropyl)-phenyl]acetate (44.4 g., 0.20 mole) in ether (300 ml.) is added dropwise during 40 minutes a solution of phosphorus tribromide (20.7 g., 0.075 mole) in ether (100 ml.). The temperature is maintained at 25°-28° C. during this time by means of a cold water bath. The reaction solution is then heated a reflux for 4 hours. It is cooled and poured into iced-water. The ether layer is separated, washed with water, dried over magnesium sulfate, and evaporated in vacuo to yield ethyl [2-(3-Bromopropyl)phenyl]acetate.

1. temperatureThe temperature is maintained at 25°-28° C. during this time by means of a cold water bath
2. temperatureThe reaction solution is then heated
3. temperaturea reflux for 4 hours
4. temperatureIt is cooled
5. customThe ether layer is separated
6. washwashed with water
7. dry with materialdried over magnesium sulfate
8. customevaporated in vacuo