HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzocaine → (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-ethoxycarbonylphenyl)-3-(tetrahydropyran-2-yloxy)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzocaine | HCID 2337 | — |
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | 2-(4-Chlorobenzenesulfonamido)-3-hydroxypropanoic acid | HCID 4229170 | — |
| Product | (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-ethoxycarbonylphenyl)-3-(tetrahydropyran-2-yloxy)propanamide | HCID 19032774 | 35.8% |
Reaction Steps
The procedure described in Example 1 was repeated, except that dihydropyran (2.7 g) and ethyl p-aminobenzoate (2.13 g) were successively reacted with (RS)-2-(4-chlorobenzenesulfonylamino)-3-hydroxypropanoic acid (3 g) to obtain (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-ethoxycarbonylphenyl)-3-(tetrahydropyran-2-yloxy)propanamide (1.962 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05650428 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-eb0a42e2a1fd493f85161636ef2d444f |
| Source note | uspto-grants-1997_07 |