Methanesulfonyl chloride → HCID 19032872, compound

HRID 266296Notes

Reaction equation

[CH2:1]([O:3][C:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:29])[CH:15]([NH:18][S:19]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)(=[O:21])=[O:20])[CH2:16][OH:17])=[CH:9][CH:8]=1)=[O:5])[CH3:2].[S:30](Cl)([CH3:33])(=[O:32])=[O:31]>>[CH2:1]([O:3][C:4]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:14](=[O:29])[CH:15]([NH:18][S:19]([C:22]2[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=2)(=[O:21])=[O:20])[CH2:16][O:17][S:30]([CH3:33])(=[O:32])=[O:31])=[CH:11][CH:12]=1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 19032727HCID 19032727, compound

Product 1

HCID 19032872HCID 19032872, compound

Procedure

The procedure described in Example 65 was repeated, except that (RS)-N-(4-(ethoxycarbonylmethyl)phenyl)-2-(4-fluorobenzenesulfonylamino)-3-hydroxypropanamide (1.88 g) was reacted with mesyl chloride to obtain (RS)-N-(4-(ethoxycarbonylmethyl)phenyl)-2-(4-fluorobenzenesulfonylamino)-3-methanesulfonyloxypropanamide (1.70 g).

Sources & evidence

ORD record: ord-7690b922225441d8a7138ba178ef1068
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05650428

Reaction notes

Loading…