Phenol → HCID 19032775, compound

HRID 266345Notes

Reaction equation

HRID 266345 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]([CH2:28][O:29]S(C)(=O)=O)[C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:18][CH:17]=2)=[O:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:34]1(O)[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]([CH2:28][O:29][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:18][CH:17]=2)=[O:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 996PhenolHCID 19032738HCID 19032738, compound

Product 1

HCID 19032775HCID 19032775, compoundYield 85.3%

Procedure

The procedure described in Example 125 was repeated, except that ((RS)-2-(4-bromobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-methanesulfonyloxypropanamide (500 mg) was reacted with phenol (167 mg) to obtain (RS)-2-(4-bromobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-phenoxypropanamide (425.22 mg).

Sources & evidence

ORD record
ord-9c9f0bbfe5b54a8691e7c1839b4ccee1
Source dataset
uspto-grants-1997_07
Patent number
US05650428

Reaction notes

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