HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → Sulfametrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Sulfanilamide | HCID 5333 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Chloro-4-methoxy-1,2,5-thiadiazole | HCID 18177248 | — |
| Product | Sulfametrole | HCID 64939 | 86% |
Reaction Steps
75.3 g of 3-methoxy-4-chloro-1,2,5-thiadiazole (0.5 mole), 103.32 g of sulfanilamide (0.6 mole) and 712.25 g of potassium carbonate (1.25 mole) were reacted in 78.13 g of dimethyl sulfoxide (1 mole) and were further treated as described in Example 1. 123.1 g of crude 3-methoxy-4-(4'-aminobenzene-sulfonamido)-1,2,5-thiadiazole (85.99% of theory) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04151164 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-bc8fb7d44eeb405193a328ad00329943 |
| Source note | uspto-grants-1979_04 |