Dicyclohexylcarbodiimide → HCID 22875028, compound

Participants

Reaction Steps

The procedure described in Example 180 was repeated, except that (S)-2-(4-chlorobenzenesulfonylamino)-4-methylthiobutanoic acid (10 g) and ethyl 3-aminobenzoate (4.1 g) were condensed in dichloromethane (80 ml) in the presence of N,N'-dicyclohexylcarbodiimide (7.65 g). The reaction mixture was filtered, and the filtrate was concentrated. The resulting crude product was recrystallized from methanol-ethyl acetate to obtain (S)-2-(4-chlorobenzenesulfonylamino)-N-(3-ethoxycarbonylphenyl)-4-methylthiobutanamide (2.13 g).

Provenance & Evidence