HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 19032782, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Alanine, N-(p-bromobenzenesulfonyl)-3-phenyl-, DL- | HCID 37799 | — |
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | Ethyl (4-aminophenyl)acetate--hydrogen chloride (1/1) | HCID 24192282 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19032782 | HCID 19032782 | 8.2% |
Reaction Steps
The procedure described in Example 179 was repeated, except that (RS)-2-(4-bromobenzenesulfonylamino)-3-phenylpropanoic acid (300.2 mg) and ethyl 4-aminophenylacetate hydrochloride (202.2 mg) were condensed in THF (5 ml) in the presence of triethylamine (422.4 μl) and pivaloyl chloride (153.9 μl), and then the resulting crude product was recrystallized from ethanol to obtain (RS)-2-(4-bromobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-phenylpropanamide (35.1 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05650428 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-3ea847b7064d4ab6869994bfc5b67c0d |
| Source note | uspto-grants-1997_07 |