HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 54015343, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | p-Aminophenylacetic acid ethyl ester | HCID 225219 | — |
| Reactant | (2S)-2-[(4-chlorophenyl)sulfonylamino]-3-(1H-indol-3-yl)propanoic acid | HCID 982211 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 54015343 | HCID 54015343 | 68.3% |
Reaction Steps
The procedure described in Example 180 was repeated, except that (S)-2-(4-chlorobenzenesulfonylamino)-3-(3-indolyl) propanoic acid (5 g) and ethyl 4-aminophenylacetate (2.36 g) were condensed in a mixed solvent of dichloromethane (100 ml) and acetonitrile (10 ml) in the presence of N,N'-dicyclohexylcarbodiimide (3.27 g). The reaction mixture was filtered, and the filtrate was concentrated. The resulting crude product was recrystallized from ethanol/acetonitrile (10/1) to obtain (S)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(3-indolyl)propanamide (4.86 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05650428 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-0ef78e9df0c641b3887f03a046663c54 |
| Source note | uspto-grants-1997_07 |