Acetic Anhydride → 2,2-Dimethylphenethyl acetate

HRID 266394Notes

Reaction equation

HRID 266394 reaction equation
[CH3:1][C:2]1([CH3:11])[CH:10]=[CH:9][CH:8]=[CH:7][CH:3]1[CH2:4][CH2:5][OH:6].[C:12](OC(=O)C)(=[O:14])[CH3:13]>N1C=CC=CC=1>[C:12]([O:6][CH2:5][CH2:4][CH:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]1([CH3:11])[CH3:1])(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 701452672,2-Dimethylphenethyl alcohol

Product 1

HCID 229063012,2-Dimethylphenethyl acetate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Dissolve 2,2-dimethylphenethyl alcohol (118.0 g, 0.786 mol) in pyridine (700 mL). Add, by dropwise addition, acetic anhydride (222 mL, 240.7 g, 2.358 mol) and stir overnight at room temperature. Evaporate the solvent in vacuo and purify by distillation to give the title compound as a clear colorless oil; bp 75° C. @0.4 mmHg.

Workup

  1. customEvaporate the solvent in vacuo
  2. distillationpurify by distillation

Sources & evidence

ORD record
ord-695ef057d1ee4508af5fda0aefd5c2cc
Source dataset
uspto-grants-1997_07
Patent number
US05650516

Reaction notes

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