HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 15392143, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| Reactant | HCID 178515057 | HCID 178515057 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 15392143 | HCID 15392143 | 58% |
Reaction Steps
Following a procedure similar to that described in Example 33A above, 1.72 g (0.005 mol) of 2-(5-mercapto-1,3,4-thiadiazol-2-ylthiomethyl)saccharin was reacted with 1.44 g (0.01 mol) of 2-dimethylaminoethyl chloride hydrochloride in 10 ml of DMF in the presence of 1.72 g (0.017 mol) of triethylamine to give 1.2 g (58%) of 2-(5-[2-(N,N-dimethylamino)ethylthio]-1,3,4-thiadiazol-2-ylthiomethyl)saccharin, mp 90.5°-91.5° C. (from ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05650422 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-8ef693afef06497fac9289b932528aba |
| Source note | uspto-grants-1997_07 |