HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 70050785, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 70052771 | HCID 70052771 | — |
| Reactant | HCID 178527989 | HCID 178527989 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 70050785 | HCID 70050785 | 74% |
Reaction Steps
A solution of 2-chloromethyl-4-ethyl-5,7-dimethoxysaccharin (Example 22L, 0.4 g) and 1-phenyltetrazol-5-thiol sodium salt (0.28 g) in dimethylformamide (3 mL) was heated at 110° C. for two hours, then poured into water. Recrystallization of the resulting solid from ethanol-water afforded 2-(1-phenyltetrazol-5-yl)thiomethyl-4-ethyl-5,7-dimethoxysaccharin, 0.44 g, 74% yield, mp 162°-164° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05650422 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-afd66602983048888110a53c51f1f181 |
| Source note | uspto-grants-1997_07 |