Hexane → HCID 70050496, compound

HRID 266464Notes

Reaction equation

HRID 266464 reaction equation
S(Cl)([Cl:4])(=O)=O.C1(S[CH2:13][N:14]2[C:24](=[O:25])[C:23]3[C:18](=[CH:19][C:20]([O:26][CH2:27][CH2:28][O:29][CH2:30][CH2:31][O:32][CH3:33])=[CH:21][CH:22]=3)[S:15]2(=[O:17])=[O:16])C=CC=CC=1.CCCCCC>ClCCl>[Cl:4][CH2:13][N:14]1[C:24](=[O:25])[C:23]2[C:18](=[CH:19][C:20]([O:26][CH2:27][CH2:28][O:29][CH2:30][CH2:31][O:32][CH3:33])=[CH:21][CH:22]=2)[S:15]1(=[O:17])=[O:16]

Participants

5

Reactant 3

HCID 8058HexaneHCID 24648Sulfuryl chlorideHCID 70050485HCID 70050485, compound

Product 1

HCID 70050496HCID 70050496, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Sulfuryl chloride (0.34 g) was added dropwise with stirring to a solution of 2-phenylthiomethyl-6-[2-(2-methoxyethoxy)ethoxy]saccharin (0.96 g) in dichloromethane. Stirring was continued at room temperature for three hours and the solution was stripped of volatiles. Dichloromethane was added and the solution was stripped again. Hexane was added to the residue and the mixture was stirred at room temperature overnight. The resulting white solid was collected and dried affording 2-chloromethyl-6-[2-(2-methoxyethoxy)-ethoxy]saccharin (0.69 g, 89% yield, mp 113°-115° C.).

Workup

  1. stirringthe mixture was stirred at room temperature overnight
  2. customThe resulting white solid was collected
  3. customdried

Sources & evidence

ORD record
ord-8d341f28d2204247a37000eb1c0191cc
Source dataset
uspto-grants-1997_07
Patent number
US05650422

Reaction notes

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