反应详情

温度

120 °C

A mixture of 0.56 g. of benzimidic acid 2-methylhydrazide hydrochloride and 3.8 g. of o-toluic acid chloride is heated under stirring at about 120° C. After cooling and addition of diethyl ether, the hydrochloride of the triazole is collected on filter and then suspended in a sodium bicarbonate aqueous solution. The free base is extracted with diethyl ether and the organic phase, after drying over sodium sulfate, is evaporated. The crude compound is purified by distillation at 160° C./0.1 mm Hg. Yield 76%.

1. additionA mixture of 0.56 g
2. temperatureAfter cooling
3. customthe hydrochloride of the triazole is collected
4. filtrationon filter
5. extractionThe free base is extracted with diethyl ether
6. dry with materialthe organic phase, after drying over sodium sulfate
7. customis evaporated
8. distillationThe crude compound is purified by distillation at 160° C./0.1 mm Hg