Sulfuryl chloride → HCID 70050615, compound

HRID 266484Notes

Reaction equation

HRID 266484 reaction equation
C1(S[CH2:8][N:9]2[C:19](=[O:20])[C:18]3[C:13](=[C:14]([O:24][CH2:25][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH:15]=[CH:16][C:17]=3[O:21][CH2:22][CH3:23])[S:10]2(=[O:12])=[O:11])C=CC=CC=1.S(Cl)([Cl:36])(=O)=O>ClCCl>[Cl:36][CH2:8][N:9]1[C:19](=[O:20])[C:18]2[C:13](=[C:14]([O:24][CH2:25][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH:15]=[CH:16][C:17]=2[O:21][CH2:22][CH3:23])[S:10]1(=[O:12])=[O:11]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 70050315HCID 70050315, compound

Product 1

HCID 70050615HCID 70050615, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

By the method of part E of Example 45 2-phenylthiomethyl-4-ethoxy-7-(t-butoxycarbonylmethoxy)saccharin (1.92 g) was reacted with sulfuryl chloride (0.54 g) in dichloromethane at about 5° C. and purified with hexane affording 2-chloromethyl-4-ethoxy-7-(t-butoxycarbonylmethoxy)saccharin, 1.54 g, 95% yield, mp 117°-119° C.

Workup

  1. custompurified with hexane

Sources & evidence

ORD record
ord-6a624b21401647c2b0f9170f0c26521b
Source dataset
uspto-grants-1997_07
Patent number
US05650422

Reaction notes

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