Acetonitrile → HCID 86747136, compound

HRID 266488Notes

Reaction equation

HRID 266488 reaction equation
Cl[CH2:2][N:3]1[C:13](=[O:14])[C:12]2[C:7](=[C:8]([O:20][CH3:21])[C:9]([O:18][CH3:19])=[CH:10][C:11]=2[CH:15]([CH3:17])[CH3:16])[S:4]1(=[O:6])=[O:5].[Na].[C:23]1([N:29]2[C:33]([SH:34])=[N:32][N:31]=[N:30]2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[C:35](#N)C>>[C:23]1([N:29]2[C:33]([S:34][CH2:2][N:3]3[C:13](=[O:14])[C:12]4[C:7](=[C:8]([O:20][CH3:21])[C:9]([O:18][CH3:19])([CH3:35])[CH2:10][C:11]=4[CH:15]([CH3:17])[CH3:16])[S:4]3(=[O:6])=[O:5])=[N:32][N:31]=[N:30]2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 70046394HCID 70046394, compoundHCID 178527989HCID 178527989, compound

Product 1

HCID 86747136HCID 86747136, compoundYield 70%

Procedure

By a method similar to that of Example 44 condensation of 2-chloromethyl-4-isopropyl-6,7-dimethoxysaccharin (0.095 g) and 1-phenyltetrazol-5-thiol sodium salt (0.120 g) in acetonitrile (2 mL) and purification of the product by crystallization from ethanol afforded 2-(1-phenyltetrazol-5-yl)thiomethyl-4-isopropyl-6,7-dimethoxy-6-methylsaccharin, 0.099 g, 70% yield, mp 169°-171° C.

Workup

  1. customby crystallization from ethanol

Sources & evidence

ORD record
ord-8948a9f1025a4072835a641835c82cc8
Source dataset
uspto-grants-1997_07
Patent number
US05650422

Reaction notes

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