HCID 70052725, compound → HCID 70050473, compound

HRID 266490Notes

Reaction equation

HRID 266490 reaction equation
Cl[CH2:2][N:3]1[C:13](=[O:14])[C:12]2[C:7](=[C:8]([OH:18])[CH:9]=[CH:10][C:11]=2[O:15][CH2:16][CH3:17])[S:4]1(=[O:6])=[O:5].[Na].[C:20]1([N:26]2[C:30]([SH:31])=[N:29][N:28]=[N:27]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(O)C>[C:20]1([N:26]2[C:30]([S:31][CH2:2][N:3]3[C:13](=[O:14])[C:12]4[C:7](=[C:8]([OH:18])[CH:9]=[CH:10][C:11]=4[O:15][CH2:16][CH3:17])[S:4]3(=[O:6])=[O:5])=[N:29][N:28]=[N:27]2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 70052725HCID 70052725, compoundHCID 178527989HCID 178527989, compound

Product 1

HCID 70050473HCID 70050473, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

By the method of part F of Example 45 condensation of 2-chloromethyl-4-ethoxy-7-hydroxysaccharin (1.95 g) and 1-phenyltetrazol-5-thiol sodium salt (1.5 g, reaction time about 8 hours) and purification of part of the product (2.5 g., 88% yield) from ethanol gave 2-(1-phenyltetrazol-5-yl)thiomethyl-4-ethoxy-7-hydroxysaccharin, mp 178°-180° C.

Sources & evidence

ORD record
ord-dd5916f3e4f346c98ca0db1f6be06a7e
Source dataset
uspto-grants-1997_07
Patent number
US05650422

Reaction notes

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